| First Author | Kelly E | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 2 | Pages | 597-603 |
| PubMed ID | 11777951 | Mgi Jnum | J:73736 |
| Mgi Id | MGI:2156336 | Doi | 10.4049/jimmunol.168.2.597 |
| Citation | Kelly E, et al. (2002) IL-2 and related cytokines can promote T cell survival by activating AKT. J Immunol 168(2):597-603 |
| abstractText | The regulated elimination of T cells serves to maintain normal immune function and prevents autoimmune responses. IL-2 family cytokines play an important role in controlling the survival of immature and mature T cells. These molecules activate the protein kinase, AKT/PKB. AKT has been shown to transduce an antiapoptotic signal in numerous cell types. In this study, we show that an active form of AKT can protect T cells from apoptosis following growth factor withdrawal and that IL-2 family cytokines can promote T cell survival by activating this kinase. We also provide evidence that AKT does not block death receptor-mediated killing of lymphocytes. These data suggest that AKT may serve as a common signaling element by which members of the IL-2 family of cytokines promote T cell survival. |
