| First Author | Hughes DC | Year | 1999 |
| Journal | Biochim Biophys Acta | Volume | 1447 |
| Issue | 2-3 | Pages | 303-6 |
| PubMed ID | 10542331 | Mgi Jnum | J:58266 |
| Mgi Id | MGI:1347151 | Doi | 10.1016/s0167-4781(99)00181-5 |
| Citation | Hughes DC, et al. (1999) Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?. Biochim Biophys Acta 1447(2-3):303-6 |
| abstractText | The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19. |
