| First Author | Kaisho Y | Year | 1999 |
| Journal | Neurosci Lett | Volume | 277 |
| Issue | 3 | Pages | 181-4 |
| PubMed ID | 10626843 | Mgi Jnum | J:60066 |
| Mgi Id | MGI:1352588 | Doi | 10.1016/s0304-3940(99)00874-5 |
| Citation | Kaisho Y, et al. (1999) Nerve growth factor promoter driven neurotrophin-3 overexpression in the mouse and the protective effect of transgene on age-related behavioral deficits. Neurosci Lett 277(3):181-4 |
| abstractText | To clarify the biological function of neurotrophin-3 (NT-3) at the postnatal stage, we created a line of transgenic mice overexpressing NT-3 under the control of the mouse nerve growth factor gene promoter. Transgenic mice showed high-level NT-3 expression in the hippocampus and several tissues. We performed behavioral tests in young-adult (7-months-old) and aged (25-months-old) mice. Although aged non-transgenic mice exhibited spatial learning impairments in the Morris water maze, overexpression of NT-3 protected against these age-dependent spatial learning impairments in mice. |
