| First Author | Randolph GJ | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 6 | Pages | 753-61 |
| PubMed ID | 10626897 | Mgi Jnum | J:59202 |
| Mgi Id | MGI:1351151 | Doi | 10.1016/s1074-7613(00)80149-1 |
| Citation | Randolph GJ, et al. (1999) Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11(6):753-61 |
| abstractText | We investigated the differentiation and trafficking of inflammatory monocytes that phagocytosed subcutaneously injected fluorescent microspheres. As expected, most of the monocytes became microsphere+ macrophages, which remained in subcutaneous tissue. However, about 25% of latex+ cells migrated to the T cell area of draining lymph nodes, where they expressed dendritic cell (DC)-restricted markers and high levels of costimulatory molecules. Microsphere-transporting cells were distinct from resident skin DCs, and this transport was reduced by more than 85% in monocyte-deficient osteopetrotic mice. Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs. |
