| First Author | Reizis B | Year | 2000 |
| Journal | Genomics | Volume | 63 |
| Issue | 1 | Pages | 149-52 |
| PubMed ID | 10662556 | Mgi Jnum | J:60628 |
| Mgi Id | MGI:1353739 | Doi | 10.1006/geno.1999.6068 |
| Citation | Reizis B, et al. (2000) Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics 63(1):149-52 |
| abstractText | We recently characterized a genomic region located upstream of the mouse pre-T cell receptor alpha (pTa) gene, which controls pTa expression in pre-T cells. We now report an unexpected homology between this region and a region in the mouse X chromosome inactivation center between the 3' end of the Xist gene and the start of an antisense transcript Tsix. The homology is extended over 4 kb of genomic sequence split by an expanded repeat region and is observed only in the mouse, not in the rat. Despite high sequence similarity to the pTa transcriptional enhancer, the homologous X chromosome fragment appears to have lost its enhancer activity. These data underscore the complex organization of the mouse genome and, in particular, of the X chromosome inactivation center. Copyright 2000 Academic Press. |
