| First Author | Nikitin AY | Year | 1999 |
| Journal | Ann N Y Acad Sci | Volume | 886 |
| Pages | 12-22 | PubMed ID | 10667199 |
| Mgi Jnum | J:60502 | Mgi Id | MGI:1353383 |
| Doi | 10.1111/j.1749-6632.1999.tb09396.x | Citation | Nikitin AY, et al. (1999) A paradigm for cancer treatment using the retinoblastoma gene in a mouse model. Ann N Y Acad Sci 886:12-22 |
| abstractText | Discovery of tumor suppressor genes has provided a rational approach to cancer prevention and treatment. Loss of retinoblastoma susceptibility gene (Rb) function is a rate-limiting event in the development of human and mouse cancers. Establishment of animal models of cancer associated with Rb deficiency allowed us to develop and test long-awaited approaches to genetic correction for treating tumors in vivo. Recent studies demonstrated that (1) prevention of carcinogenesis is achieved by correction of gene copy number in Rb+/- mice, and (2) reconstitution of Rb gene functions is sufficient for suppression of neoplasia in immunocompetent mice. These results fulfill a promise of cancer treatment by reconstitution of tumor suppressor function. |
