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Publication : Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse.

First Author  Dragatsis I Year  2000
Journal  Neurosci Lett Volume  282
Issue  1-2 Pages  37-40
PubMed ID  10713390 Mgi Jnum  J:63338
Mgi Id  MGI:1860786 Doi  10.1016/s0304-3940(00)00872-7
Citation  Dragatsis I, et al. (2000) Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse. Neurosci Lett 282(1-2):37-40
abstractText  Huntingtin-associated protein 1 (HAP1) interacts with the product of the Huntington's disease gene. To investigate the function of Hap1 in development and in the adult mouse, we have examined the expression of Hap1 by northern analysis and in situ hybridization histochemistry. Hap1 expression is first detected in the embryonic day 8.5 (E8.5) neuroepithelium. Expression persists throughout development, predominantly in the brain and spinal cord, and to a lesser extent in enteric neurons and abdominal sympathetic ganglia. In the adult, Hap1 expression is detected not only in the brain but also in the ovary, testis, and the intermediate lobe of the pituitary.
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