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Publication : Principles of animal use for gerontological research.

First Author  Miller RA Year  2000
Journal  J Gerontol A Biol Sci Med Sci Volume  55
Issue  3 Pages  B117-23
PubMed ID  10795715 Mgi Jnum  J:61928
Mgi Id  MGI:1855784 Doi  10.1093/gerona/55.3.B117
Citation  Miller RA, et al. (2000) Principles of animal use for gerontological research. J Gerontol A Biol Sci Med Sci 55(3):B117-23
abstractText  This essay presents some practical advice and suggestions for those who wish to use mice and rats in experiments on the biology of aging. Ten principles set forth guidance on choice of ages, choice of stocks, the importance of specific pathogen-free status, the uses of necropsy data, the dangers of pooling samples from different individuals, planning ahead for loss of aged mice to death and disease, the use of cost-adjusted power calculations, and the dangers of inferring causal associations from correlated age effects.
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