| First Author | Ehlers S | Year | 2000 |
| Journal | Infect Immun | Volume | 68 |
| Issue | 6 | Pages | 3720-3 |
| PubMed ID | 10816534 | Mgi Jnum | J:62246 |
| Mgi Id | MGI:1858636 | Doi | 10.1128/iai.68.6.3720-3723.2000 |
| Citation | Ehlers S, et al. (2000) Gamma interferon is essential for clearing Mycobacterium genavense infection. Infect Immun 68(6):3720-3 |
| abstractText | Factors determining the in vivo replication of the opportunistic pathogen Mycobacterium genavense are largely unknown. Following intravenous injection of a patient isolate, M. genavense could not be recovered by culture or detected by PCR in the livers or spleens of infected BALB/c mice. In contrast, M. genavense was found to chronically persist and multiply in the livers and spleens of intravenously infected syngeneic gamma-interferon-gene-deficient (GKO) mice as evidenced by acid-fast stains of infected tissues and recovery by both PCR and liquid culture following organ homogenization. In GKO mice, M. genavense elicited a chronic inflammatory response, resulting in marked splenomegaly and extensive lymphadenopathy. Granulomatous lesions in the livers of GKO mice were diffuse, were composed of monocytes, neutrophils, and CD3(+) cells, and were histochemically negative for inducible nitric oxide synthase. |
