| First Author | Feldman JD | Year | 2000 |
| Journal | J Neurochem | Volume | 74 |
| Issue | 6 | Pages | 2227-38 |
| PubMed ID | 10820182 | Mgi Jnum | J:62077 |
| Mgi Id | MGI:1858309 | Doi | 10.1046/j.1471-4159.2000.0742227.x |
| Citation | Feldman JD, et al. (2000) The salt-inducible kinase, SIK, is induced by depolarization in brain. J Neurochem 74(6):2227-38 |
| abstractText | Membrane depolarization of neurons is thought to lead to changes in gene expression that modulate neuronal plasticity. We used representational difference analysis to identify a group of cDNAs that are induced by membrane depolarization or by forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. One of these genes, SIK (salt-inducible kinase), is a member of the sucrose-nonfermenting 1 protein kinase/AMP-activated protein kinase protein kinase family that was also recently identified from the adrenal gland of rats treated with high-salt diets. SIK mRNA is induced up to eightfold in specific regions of the hippocampus and cortex in rats, following systemic kainic acid administration and seizure induction. |
