| First Author | Sommer A | Year | 2000 |
| Journal | FEBS Lett | Volume | 474 |
| Issue | 2-3 | Pages | 146-50 |
| PubMed ID | 10838075 | Mgi Jnum | J:62682 |
| Mgi Id | MGI:1859452 | Doi | 10.1016/s0014-5793(00)01566-0 |
| Citation | Sommer A, et al. (2000) Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc. FEBS Lett 474(2-3):146-50 |
| abstractText | Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1. |
