First Author | Kortschak RD | Year | 2000 |
Journal | Trends Biochem Sci | Volume | 25 |
Issue | 6 | Pages | 294-9 |
PubMed ID | 10838570 | Mgi Jnum | J:62745 |
Mgi Id | MGI:1859519 | Doi | 10.1016/s0968-0004(00)01597-8 |
Citation | Kortschak RD, et al. (2000) ARID proteins come in from the desert. Trends Biochem Sci 25(6):294-9 |
abstractText | Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure. |