| First Author | Lammert E | Year | 2000 |
| Journal | Mech Dev | Volume | 94 |
| Issue | 1-2 | Pages | 199-203 |
| PubMed ID | 10842072 | Mgi Jnum | J:63189 |
| Mgi Id | MGI:1860583 | Doi | 10.1016/s0925-4773(00)00317-8 |
| Citation | Lammert E, et al. (2000) Notch gene expression during pancreatic organogenesis. Mech Dev 94(1-2):199-203 |
| abstractText | Notch receptors are involved in regulating the balance between cell differentiation and stem cell proliferation during the development of numerous tissues (Artavanis-Tsakonas, S., Matsuno, K., Fortini, M. E., 1995. Notch signaling. Science 268, 225-232). Here the expression of all four vertebrate Notch genes, their ligands, and some down-stream targets is analyzed during mouse pancreatic organogenesis. Notch 1 is the first Notch gene expressed in the pancreatic epithelium, and coexpression with HES 1 suggests that the Notch 1 pathway is activated. Notch 2 expression follows later when pancreatic buds branch and is restricted to embryonic ducts, believed to be the source for endocrine and exocrine stem cells. Notch 3 and Notch 4 are expressed in pancreatic mesenchyme and later in endothelial cells. Together these descriptive data comprise a framework for understanding the cellular basis for Notch function during pancreatic development. |
