| First Author | Akira S | Year | 2000 |
| Journal | Oncogene | Volume | 19 |
| Issue | 21 | Pages | 2607-11 |
| PubMed ID | 10851059 | Mgi Jnum | J:62695 |
| Mgi Id | MGI:1859465 | Doi | 10.1038/sj.onc.1203478 |
| Citation | Akira S (2000) Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 19(21):2607-11 |
| abstractText | The physiological role of each individual STAT protein is now being examined through the study of 'knockout' (KO) mice, harboring a null allele for the particular gene. In contrast to other STATs deficient mice that are born alive, STAT3-deficient mice die during early embryogenesis. However, the role of STAT3 in adult tissues can be assessed by utilizing the Cre-loxP recombination system to ablate the gene in later life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3 plays a crucial role in a variety of biological functions including cell growth, suppression and induction of apoptosis, and cell motility. Oncogene (2000). |
