| First Author | Cai J | Year | 2000 |
| Journal | Genesis | Volume | 27 |
| Issue | 1 | Pages | 6-11 |
| PubMed ID | 10862150 | Mgi Jnum | J:63323 |
| Mgi Id | MGI:1860757 | Doi | 10.1002/1526-968x(200005)27:1<6::aid-gene20>3.0.co;2-o |
| Citation | Cai J, et al. (2000) Evidence for the differential regulation of nkx-6.1 expression in the ventral spinal cord and foregut by shh-dependent and -independent mechanisms. Genesis 27(1):6-11 |
| abstractText | Summary: The Nkx-6.1 homeodomain transcription factor was previously shown to be expressed in ventral neural progenitor cells and subsequently subsets of unidentified motor neurons during early neural development. In this study, we identify a specific subpopulation of motor neurons, the median half of the lateral motor neuron column (LMCm), that retain a strong expression of Nkx-6.1. In addition, we report novel patterns of Nkx-6.1 expression in several mesenchymal tissues surrounding Sonic hedgehog (Shh)-expressing cells, including ventral spinal meninges, esophageal mesenchyme, and dorsal tracheal mesenchyme. Whereas Shh signaling is required for Nkx-6.1 expression in the ventral neural tube and spinal meninges, an Shh-independent pathway appears to operate in regulating Nkx-6.1 expression in the foregut. The persistent and robust expression of Nkx-6.1 in motor neurons and mesenchymal cells suggests an important role for Nkx-6.1 in controlling cell fate specification and differentiation. genesis 27:6-11, 2000. Copyright 2000 Wiley-Liss, Inc. |
