| First Author | Hoyne GF | Year | 2000 |
| Journal | Immunology | Volume | 100 |
| Issue | 3 | Pages | 281-8 |
| PubMed ID | 10929049 | Mgi Jnum | J:63401 |
| Mgi Id | MGI:1860972 | Doi | 10.1046/j.1365-2567.2000.00073.x |
| Citation | Hoyne GF, et al. (2000) T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling. Immunology 100(3):281-8 |
| abstractText | Recognition of antigen by T cells in the periphery may lead either to the generation of productive immunity or the induction of tolerance. These two functional outcomes are a consequence of distinct pathways of T-cell differentiation. T cells are selected to become regulatory cells and their function is to maintain homeostasis with the immune system. In this review we discuss the cell-fate decisions that T cells might make allowing them to promote immunity or induce tolerance in the context of the role that Notch signalling may play in this process. |
