| First Author | Hanley NA | Year | 2000 |
| Journal | Mol Cell Endocrinol | Volume | 163 |
| Issue | 1-2 | Pages | 27-32 |
| PubMed ID | 10963870 | Mgi Jnum | J:63910 |
| Mgi Id | MGI:1888398 | Doi | 10.1016/s0303-7207(99)00237-3 |
| Citation | Hanley NA, et al. (2000) Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Mol Cell Endocrinol 163(1-2):27-32 |
| abstractText | The orphan nuclear receptor steroidogenic factor 1 (SF-1) was identified originally as a key regulator of the tissue-specific expression of the cytochrome P450 steroid hydroxylases. Hints at considerably broader roles for SF-1 came from analyses of its expression pattern in mouse embryos. As anticipated, SF-1 was expressed in the adrenal glands and gonads from their early stages of development. Surprisingly, SF-1 also was expressed outside of the primary steroidogenic tissues in the anterior pituitary and hypothalamus. SF-1 knockout mice dramatically confirmed its multiple essential roles in vivo. These mice lacked adrenal glands and gonads, leading to adrenocortical insufficiency and male-to-female sex reversal of their internal and external genitalia. SF-1 knockout mice also had impaired pituitary expression of gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic-pituitary-gonadal axis. With some focus on the ovary, this review summarizes experiments that have defined essential roles of SF-1 in endocrine development, and highlights important areas for future studies. |
