| First Author | Kannius-Janson M | Year | 2000 |
| Journal | Biochem J | Volume | 351 Pt 2 |
| Pages | 367-76 | PubMed ID | 11023822 |
| Mgi Jnum | J:65537 | Mgi Id | MGI:1926710 |
| Citation | Kannius-Janson M, et al. (2000) The tissue-specific regulation of the carboxyl ester lipase gene in exocrine pancreas differs significantly between mouse and human. Biochem J 351 Pt 2:367-76 |
| abstractText | The carboxyl ester lipase (CEL) gene is highly expressed in exocrine pancreas and expression of the human CEL gene is mediated by a strong tissue-specific enhancer, which is absolutely necessary for high-level expression. The mouse promoter, on the other hand, does not contain a corresponding enhancer element, but instead is totally dependent on another pancreas-specific element. This element is identified as a pancreatic transcription factor 1 (PTF 1)-binding site. The human CEL promoter also contains a putative PTF 1 element located at a position corresponding to the essential PTF 1 site in the mouse promoter. However, nucleotide changes in the human promoter 5' flanking this PTF 1 site have created an overlapping CCAAT/enhancer-binding protein (C/EBP)-like binding motif, interfering with the binding of PTF 1. Hence, our findings provide an example of genetic divergence between species not accompanied by difference in function. |
