| First Author | Wijnhoven SW | Year | 2000 |
| Journal | Oncogene | Volume | 19 |
| Issue | 43 | Pages | 5034-7 |
| PubMed ID | 11042691 | Mgi Jnum | J:65355 |
| Mgi Id | MGI:1926408 | Doi | 10.1038/sj.onc.1203844 |
| Citation | Wijnhoven SW, et al. (2000) Age-dependent spontaneous mutagenesis in xpc mice defective in nucleotide excision repair. Oncogene 19(43):5034-7 |
| abstractText | DNA damages caused by cellular metabolites and environmental agents induce mutations, that may predispose to cancer. Nucleotide excision repair (NER) is a major cellular defence mechanism acting on a variety of DNA lesions. Here, we show that spontaneous mutant frequencies at the Hprt gene increased 30-fold in T-lymphocytes of 1 year old Xpc-/- mice, possessing only functional transcription-coupled repair (TCR). Hprt mutant frequencies in Xpa-/- and Csb-/- mice that both have a defect in this NER subpathway, remained low during ageing. In contrast to current models, the elevated mutation rate in Xpc-/- mice does not lead to an increased tumour incidence or premature ageing. Oncogene (2000) 19, 5034 - 5037 |
