| First Author | Westermark P | Year | 1976 |
| Journal | Scand J Immunol | Volume | 5 |
| Issue | 1-2 | Pages | 31-6 |
| PubMed ID | 57640 | Mgi Jnum | J:31041 |
| Mgi Id | MGI:78349 | Doi | 10.1111/j.1365-3083.1976.tb02989.x |
| Citation | Westermark P, et al. (1976) Coexistence of protein AA and immunoglobulin light-chain fragments in amyloid fibrils. Scand J Immunol 5(1-2):31-6 |
| abstractText | Coexistence of amyloid fibril protein AA and homogeneous immunoglobulin light-chain fragments was found in the isolated amyloid fibrils of two patients with amyloidosis secondary to rheumatoid arthritis. The light-chain amyloid fibril protein showed antigenic identity with a light-chain amyloid from a patient with primary amyloidosis, which was identified as the VlambdaIV subgroup by amino acid sequence analysis. In the amyloid fibrils isolated from another patient with primary amyloidosis there was a mixture of VlambdaIV and VlambdaV homogeneous immunoglobulin light chains. Thus, a mixture of protein AA had lambda light chains or two different types of homogeneous light chains may be found in the amyloid fibrils of some patients. |
