| First Author | Frelinger JA | Year | 1976 |
| Journal | J Exp Med | Volume | 144 |
| Issue | 4 | Pages | 1141-6 |
| PubMed ID | 62014 | Mgi Jnum | J:5712 |
| Mgi Id | MGI:54189 | Doi | 10.1084/jem.144.4.1141 |
| Citation | Frelinger JA, et al. (1976) Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A-reactive cells to the I-J subregion of the H-2 gene complex. J Exp Med 144(4):1141-6 |
| abstractText | We have shown that the Ia determinants expressed on nylon wool-purified T lymphocytes reactive to concanavalin A (Con A) in serum-free media are coded in a single I subregion of the H-2 gene complex. This region, I-J, is defined by two pairs of intra-H-2 recombinant haplotypes: H-2t3, H-2t4 and H-2i3, H-2i5, carried by B10.HTT, B10.S(9R), B10.A(3R), AND B10.A(5R), respectively. No activity against Con A-reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I-J region. This suggests that Ia antigens expressed on Con A-reactive T cells are restricted to the I-J subregion. |
