| First Author | Glimcher L | Year | 1977 |
| Journal | J Exp Med | Volume | 145 |
| Issue | 1 | Pages | 1-9 |
| PubMed ID | 187714 | Mgi Jnum | J:5742 |
| Mgi Id | MGI:54219 | Doi | 10.1084/jem.145.1.1 |
| Citation | Glimcher L, et al. (1977) Identification of a cell-surface antigen selectively expressed on the natural killer cell. J Exp Med 145(1):1-9 |
| abstractText | We have studied the cell-surface phenotype of natural killer (NK) cells of NZB and B6 mice which react to an MuLV+ lymphoid tumor. (a) NK cells do not express Thy1, Ly2, or Ig surface markers. (b) NK cells express an antigen recognized by C3H anti-CE antiserum ('anti-Ly1.2 antiserum'). Inasmuch as NK activity of spleen cells from B6 and B6/Ly1.1 congenic strains were both equally sensitive to C3H anti-CE antiserum, the NK antigen is distinct from Ly1.2. This point was confirmed by the observation that alphaNK activity was removed by absorption of C3H anti-CE antiserum with spleen cells from either B6 or B6/Ly1.1 congenic strains. Absorption of C3H alphaCE serum with BALB/c thymocytes and spleen cells (which are Ly1.2+NK-) removed anti-Ly1.2 activity and left anti-NK activity intact. This absorption step could be circumvented by inserting the BALB/c genotype into the recipient immunized to CE cells (i.e., (C3H X BALB/c)F1 alphaCE spleen cells). This antiserum, provisionally termed 'anti-NK', defines a new subclass of lymphocytes which may play a central role in the immunosurveillance against tumors. |
