| First Author | Hansen TH | Year | 1977 |
| Journal | J Immunol | Volume | 118 |
| Issue | 4 | Pages | 1403-8 |
| PubMed ID | 66293 | Mgi Jnum | J:5791 |
| Mgi Id | MGI:54268 | Doi | 10.4049/jimmunol.118.4.1403 |
| Citation | Hansen TH, et al. (1977) Genetic control of the humoral response to an H-2 public specificity. J Immunol 118(4):1403-8 |
| abstractText | The humoral response of mice to an H-2 public specificity, termed H-2. '28' was found to be under genetic control. The genes determining this specificity were mapped to both the H-2K and H-2D regions, suggesting possible structural homologies between the products determined by these two regions. Genetic analyses indicated that a single non-H-2-linked gene regulates the anti-H-2. '28' response. In a backcross study, no linkage was detected between this putative H-2. '28' Ir gene and either the V H region or the Ly-2 locus to which the K-light chain locus is linked. Thus, a regulatory rather than a structural genetic locus seems a more likely basis for differences in response to this antigen. Our data further indicate that control of the humoral response to H-2. '28' is determinant specific since responses of the same backcross mice to other K and D alloantigens were not found to be subject to the same control. |
