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Publication : Lymphocytes alloantigens associated with X-chromosome-linked immune response genes.

First Author  Zeicher M Year  1977
Journal  Proc Natl Acad Sci U S A Volume  74
Issue  2 Pages  721-4
PubMed ID  265535 Mgi Jnum  J:5793
Mgi Id  MGI:54270 Doi  10.1073/pnas.74.2.721
Citation  Zeicher M, et al. (1977) Lymphocytes alloantigens associated with X-chromosome-linked immune response genes. Proc Natl Acad Sci U S A 74(2):721-4
abstractText  A new polymorphic alloantigen system controlled by loci on the X-chromosome has been identified by using antisera from F1 hybrid mice differing in their X-chromosome. These alloantigens are associated with the X-chromosome. These alloantigens are associated with the X-linked immune response genes controlling the immune response to the so-called thymus independent antigens such as type III pneumococcal polysaccharide, poly(I)-poly(C), and denatured DNA. They also show association with the histocompatibility locus present on the X-chromosome. They were mainly detected on a not yet characterized thymus-derived lymphocyte subpopulation. A certain similarity with the major histocompatibility complex of the mouse supports the possibility of additional I-like regions besides the I region of the histocompatibility-2 complex.
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