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Publication : Genes controlling receptors for ecotropic and xenotropic type C virus in Mus cervicolor and Mus musculus.

First Author  Marshall TH Year  1979
Journal  J Virol Volume  29
Issue  2 Pages  501-6
PubMed ID  219245 Mgi Jnum  J:6114
Mgi Id  MGI:54591 Doi  10.1128/jvi.29.2.501-506.1979
Citation  Marshall TH, et al. (1979) Genes controlling receptors for ecotropic and xenotropic type C virus in Mus cervicolor and Mus musculus. J Virol 29(2):501-6
abstractText  Gene loci controlling cell surface receptors for murine leukemia virus were studied by using murine X Chinese hamster hybrid cells. Hybrids which exclusively segregate murine chromosomes were made by fusing Mus cervicolor and Mus musculus lymphocytes to hamster fibroblasts. Sensitivity to Moloney murine leukemia virus infecotion and specific binding of the envelope glycoprotein of Rauscher murine leukemia virus (gp70) cosegregate and isozyme analysis show an association with chromosome 5 in both species. With the possible exception of one clone, no evidence was found for a proviral integration site independent of chromosome 5. Evidence is presented for additional unlinked ectropic and xenotropic receptors independent of chromosome 5.
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