| First Author | Subbarao B | Year | 1979 |
| Journal | J Immunol | Volume | 122 |
| Issue | 6 | Pages | 2279-85 |
| PubMed ID | 312864 | Mgi Jnum | J:6139 |
| Mgi Id | MGI:54616 | Doi | 10.4049/jimmunol.122.6.2279 |
| Citation | Subbarao B, et al. (1979) Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus. J Immunol 122(6):2279-85 |
| abstractText | Anti-Lyb-5.1 serum contains antibodies against two different B cell surface antigenic determinants, Lyb-5.1 and Lyb-7.1, which are defined in cytotoxicity and functional tests, respectively. The antibody against Lyb-7.1 is identified by its ability to specifically inhibit in vitro primary antibody responses to TNP-Ficoll. Anti-Lyb-5.1 serum can be made monospecific for anti-Lyb-7.1 activity by absorption with spleen cells from AL/N mice which have been typed as Lyb-5.1+, Lyb-7.1-. Lyb-5.1 and Lyb-7.1 are each under control of one or one set of closely linked genes. The loci specifying Lyb-5.1 and Lby-7.1 are not linked to each other nor to M1s and H-2 loci. However, the gene controlling the expression of Lyb-7.1 is linked to the genes coding for the constant region of immunoglobulin heavy chains. |
