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Publication : Activity of lymphoid cells separated from mammary tumors in blastogenesis and Winn assays.

First Author  Blazar BA Year  1980
Journal  J Natl Cancer Inst Volume  65
Issue  2 Pages  405-10
PubMed ID  6931258 Mgi Jnum  J:46450
Mgi Id  MGI:1199223 Citation  Blazar BA, et al. (1980) Activity of lymphoid cells separated from mammary tumors in blastogenesis and Winn assays. J Natl Cancer Inst 65(2):405-10
abstractText  Lymphoid cells isolated from mouse mammary tumors by isokinetic gradients were not stimulated in vitro by either phytohemagglutinin or a soluble, tumor-associated antigen extract even though splenocytes from the tumor-bearing mice were responsive to both. In in vivo Winn assays, lymphoid cells isolated from tumors markedly stimulated tumor growth rate. The effect on growth rate was abrogated by exposure of the isolated lymphoid cells to antilymphocyte serum and complement.
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