| First Author | Yaoita Y | Year | 1980 |
| Journal | Nature | Volume | 286 |
| Issue | 5776 | Pages | 850-3 |
| PubMed ID | 6774261 | Mgi Jnum | J:6381 |
| Mgi Id | MGI:54857 | Doi | 10.1038/286850a0 |
| Citation | Yaoita Y, et al. (1980) Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome. Nature 286(5776):850-3 |
| abstractText | We have studied the organization of immunoglobulin heavy-chain genes in a gamma 2b-chain (BALB/c allotype)-producing myeloma BKC F1 # 15 induced in a F1 mouse between C57BL and BALB/c. Southern blot hybridization studies using cloned mu, gamma 1 and gamma 2b-chain genes as probes demonstrate that the mu- and gamma 1-chain genes of the expressed chromosome are deleted while these genes of the unexpressed chromosome are retained. The gamma 2b-chain gene of the expressed allele is rearranged while that gene of the unexpressed allele seems unchanged, as do the gamma 2a-chain genes. These results support the allelic deletion mechanism in heavy-chain class switch and the order of H chain genes. |
