| First Author | Roeder W | Year | 1981 |
| Journal | Proc Natl Acad Sci U S A | Volume | 78 |
| Issue | 1 | Pages | 474-8 |
| PubMed ID | 6264445 | Mgi Jnum | J:20258 |
| Mgi Id | MGI:68364 | Doi | 10.1073/pnas.78.1.474 |
| Citation | Roeder W, et al. (1981) Linkage of the four gamma subclass heavy chain genes. Proc Natl Acad Sci U S A 78(1):474-8 |
| abstractText | The genes for the heavy-chain constant regions of the four gamma subclass immunoglobulins were identified in a set of overlapping mouse DNA fragments representing about 100 kilobase pairs (kb) of the mouse genome that was cloned from bacteriophage lambda libraries of BALB/c mouse embryo DNA. R-loop mapping studies show that the genes are located 5'-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-3' and lie in the same transcriptional orientation. Two DNA segments, one of 19 kb and another of 15 kb, that surround the C gamma 2b and C gamma 2a genes, respectively, show considerable homology and implicate a tandem duplication mechanism in the evolution of this gene cluster. |
