| First Author | Briles DE | Year | 1981 |
| Journal | J Immunol | Volume | 127 |
| Issue | 3 | Pages | 906-11 |
| PubMed ID | 6790621 | Mgi Jnum | J:6562 |
| Mgi Id | MGI:55037 | Doi | 10.4049/jimmunol.127.3.906 |
| Citation | Briles DE, et al. (1981) A genetic locus responsible for salmonella susceptibility in BSVS mice is not responsible for the limited T-dependent immune responsiveness of BSVS mice. J Immunol 127(3):906-11 |
| abstractText | BSVS mice are known to be highly susceptible to salmonella infection. We have shown that the bulk of the difference in susceptibility between BSVS and salmonella-resistant A/J mice is the result of a genetic difference at a single locus not closely linked to H-2, Igh-C, or Hbb, and not X-linked. We have backcrossed the A/J allele at this locus into BSVS mice for 8 successive generations and have demonstrated that the salmonella resistance afforded by this allele is not the result of a restoration of the generalized poor T-dependent responsiveness of BSVS mice. The salmonella resistance locus we have examined with these 2 strains is probably the same as the Ity locus described by others. |
