| First Author | Singh L | Year | 1982 |
| Journal | Cell | Volume | 28 |
| Issue | 2 | Pages | 205-16 |
| PubMed ID | 7060127 | Mgi Jnum | J:6698 |
| Mgi Id | MGI:55171 | Doi | 10.1016/0092-8674(82)90338-5 |
| Citation | Singh L, et al. (1982) Sex reversal in the mouse (Mus musculus) is caused by a recurrent nonreciprocal crossover involving the x and an aberrant y chromosome. Cell 28(2):205-16 |
| abstractText | Satellite DNA (Bkm) from the W sex-determining chromosome of snakes, which is related to sequences on the mouse Y chromosome, has been used to analyze the DNA and chromosomes of sex-reversed (Sxr) XXSxr male mice. Such mice exhibit a male-specific Southern blot Bkm hybridization pattern, consistent with the presence of Y-chromosome DNA. In situ hybridization of Bkm to chromosomes of XXSxr mice shows an aberrant concentration of related sequences on the distal terminus of a large mouse chromosome. The XYSxr carrier male, however, shows a pair of small chromosomes, which are presumed to be aberrant Y derivatives. Meiosis in the XYSxr mouse involves transfer of chromatin rich in Bkm-related DNA from the Y-Y1 complex to the X distal terminus. We suggest that this event is responsible for the transmission of the Sxr trait. |
