| First Author | Tulchin N | Year | 1981 |
| Journal | Genetics | Volume | 99 |
| Issue | 1 | Pages | 109-16 |
| PubMed ID | 6122625 | Mgi Jnum | J:17772 |
| Mgi Id | MGI:65800 | Doi | 10.1093/genetics/99.1.109 |
| Citation | Tulchin N, et al. (1981) gamma-Glutamyl cyclotransferase: a new genetic polymorphism in the mouse (Mus musculus) linked to Lyt-2. Genetics 99(1):109-16 |
| abstractText | Electrophoretically variant forms of gamma-glutamyl cyclotransferase have been identified in red cells of inbred mouse strains. Each inbred strain exhibited a major band of activity and a minor band that migrated more anodally. The polymorphism affects the migration of both the major and minor bands in a similar way. F1 hybrids between strains with fast forms (A/J) and strains with the slow forms (C57BL/6J) exhibited a four-banded pattern consistent with co-dominant inheritance. The patterns observed in backcross and F2 mice were consistent with the segregation of a pair of autosomal co-dominant alleles. Recombinant inbred strains and a congenic strain were used to show that the locus controlling gamma-glutamyl cyclotransferase (Ggc) is linked to Lyt-2, a lymphocyte alloantigen locus on chromosome 6, with an estimated map distance of 5.0 +/- 2.5 centimorgans. |
