| First Author | Trowbridge IS | Year | 1982 |
| Journal | J Cell Physiol | Volume | 112 |
| Issue | 3 | Pages | 403-10 |
| PubMed ID | 6290505 | Mgi Jnum | J:30966 |
| Mgi Id | MGI:78248 | Doi | 10.1002/jcp.1041120314 |
| Citation | Trowbridge IS, et al. (1982) Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody. J Cell Physiol 112(3):403-10 |
| abstractText | A rat monoclonal antibody against the murine transferrin receptor has been identified. The receptor is a 95,000 molecular weight species that exists in the cell membrane as a disulphide-bonded dimer. Whereas 29 of 29 murine hematopoietic tumor cell lines express detectable numbers of transferrin receptors, less than 1% of adult thymocytes or spleen cells and only 5% of bone marrow cells are positive. However, fetal liver and neonatal spleen contain substantial numbers of transferrin receptor-positive cells. Induction of Friend cells in vitro with dimethyl-sulphoxide leads to an overall increase in the expression of transferrin receptors on the cell surface. The anti-transferrin receptor antibody we have obtained partially blocks iron uptake from 59Fe-transferrin by a variety of murine cell lines and inhibits the growth of a murine myeloma cell line in vitro. |
