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Publication : Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.

First Author  Capon DJ Year  1983
Journal  Nature Volume  302
Issue  5903 Pages  33-7
PubMed ID  6298635 Mgi Jnum  J:20233
Mgi Id  MGI:68341 Doi  10.1038/302033a0
Citation  Capon DJ, et al. (1983) Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature 302(5903):33-7
abstractText  DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least four exons, and that only a single point mutation residing within the first exon distinguishes the coding region of both alleles of the normal gene from their activated counterpart. Both versions of the gene encode a protein which is predicted to differ from the corresponding viral gene product at three amino acid residues, one of which was previously shown to represent the major site of phosphorylation of the viral polypeptide.
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