| First Author | Beisel KW | Year | 1983 |
| Journal | Proc Soc Exp Biol Med | Volume | 172 |
| Issue | 4 | Pages | 488-91 |
| PubMed ID | 6844357 | Mgi Jnum | J:7053 |
| Mgi Id | MGI:55524 | Doi | 10.3181/00379727-172-41592 |
| Citation | Beisel KW, et al. (1983) Dominant susceptibility effect on the murine corneal response to Pseudomonas aeruginosa. Proc Soc Exp Biol Med 172(4):488-91 |
| abstractText | Natural host resistance to Pseudomonas aeruginosa corneal infection is regulated by two complementing dominant genes PsCR1 and PsCR2 (RS Berk, MA Leon, LD Hazlett. Infect Immun 26:1221-1223, 1979). In this study we have demonstrated a third dominant gene, which determines susceptibility to P. aeruginosa-induced eye damage. This gene was designated as PsCS. The F1 progeny from matings between the resistant DBA/2J strain and the susceptible strain C57BL/6J and C3H/HeJ displayed the susceptibility phenotype. Backcross and F2 studies using the C3H/HeJ and DBA/2J strains suggested the presence of two linked PsCS loci. |
