| First Author | Closs O | Year | 1983 |
| Journal | Scand J Immunol | Volume | 18 |
| Issue | 1 | Pages | 59-63 |
| PubMed ID | 6348937 | Mgi Jnum | J:7152 |
| Mgi Id | MGI:55623 | Doi | 10.1111/j.1365-3083.1983.tb00836.x |
| Citation | Closs O, et al. (1983) H-2-linked gene(s) influence the granulomatous reaction to viable Mycobacterium lepraemurium in the mouse. Scand J Immunol 18(1):59-63 |
| abstractText | The genetic control of the granulomatous response to viable Mycobacterium lepraemurium (MLM) was studied in C3H and C57BL/6 inbred strains, BXH recombinant inbred strains, (C3H X C57BL) F1 hybrids, and backcross mice. The results indicate that an autosomal dominant gene, or linked complex of genes, has a marked influence on the footpad reaction to viable MLM. The distribution of responders and non-responders among 12 BXH recombinant inbred strains and linkage analysis in C3H X (C3H X C57BL)F1 backcross mice indicated that the response gene(s) are linked to the H-2 complex on chromosome 17. The same gene(s) also influence host restriction of MLM multiplication and thus appear to be the first H-2-linked gene(s) influencing resistance to a bacterial infection. |
