| First Author | Gibson DM | Year | 1983 |
| Journal | Immunogenetics | Volume | 18 |
| Issue | 2 | Pages | 111-6 |
| PubMed ID | 6411613 | Mgi Jnum | J:7166 |
| Mgi Id | MGI:55637 | Doi | 10.1007/BF00368538 |
| Citation | Gibson DM, et al. (1983) Recombination between kappa chain genetic markers and the Lyt-3 locus. Immunogenetics 18(2):111-6 |
| abstractText | Recombination has been detected for the first time between chromosome 6 loci controlling kappa chain expression in normal mouse serum immunoglobulin and the Lyt-3 locus. The recombination event occurred at the 26th or 27th backcross generation during the derivation of the Lyt-2a, Lyt-3a-congenic line B6.PL(85NS). The line is now homozygous for the Lyt-2a, Lyt-3a allele(s) at N30F13 and homozygous animals express the Igk-Ef1b allele derived from C57BL/6. The frequency of recombination has been estimated to be 0.30% based on the present results and previous studies in which no recombination was detected. The results rule out the hypothesis that the Lyt-3 locus itself controls the light chain phenotype observed in normal serum immunoglobulin. |
