First Author | Peters G | Year | 1984 |
Journal | Mol Cell Biol | Volume | 4 |
Issue | 2 | Pages | 375-8 |
PubMed ID | 6321961 | Mgi Jnum | J:7351 |
Mgi Id | MGI:55822 | Doi | 10.1128/mcb.4.2.375 |
Citation | Peters G, et al. (1984) Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol 4(2):375-8 |
abstractText | Two regions of mouse DNA which constitute common provirus integration sites in tumors induced by mouse mammary tumor virus have been identified and designated int-1 and int-2. By examining a series of hamster-mouse somatic cell hybrids, we mapped the int-2 locus to mouse chromosome 7 and confirmed the previous assignment of int-1 to chromosome 15. This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease. |