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Publication : Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes.

First Author  Peters G Year  1984
Journal  Mol Cell Biol Volume  4
Issue  2 Pages  375-8
PubMed ID  6321961 Mgi Jnum  J:7351
Mgi Id  MGI:55822 Doi  10.1128/mcb.4.2.375
Citation  Peters G, et al. (1984) Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol 4(2):375-8
abstractText  Two regions of mouse DNA which constitute common provirus integration sites in tumors induced by mouse mammary tumor virus have been identified and designated int-1 and int-2. By examining a series of hamster-mouse somatic cell hybrids, we mapped the int-2 locus to mouse chromosome 7 and confirmed the previous assignment of int-1 to chromosome 15. This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease.
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