| First Author | Chiu IM | Year | 1984 |
| Journal | Cell | Volume | 37 |
| Issue | 1 | Pages | 123-9 |
| PubMed ID | 6327048 | Mgi Jnum | J:7437 |
| Mgi Id | MGI:55907 | Doi | 10.1016/0092-8674(84)90307-6 |
| Citation | Chiu IM, et al. (1984) Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor. Cell 37(1):123-9 |
| abstractText | The simian sarcoma virus transforming gene, v-sis, encodes a protein, p28sis , that is closely related to human platelet-derived growth factor (PDGF). The human locus related to v-sis was cloned and shown to contain at least five exons corresponding to the v-sis coding region. Nucleotide sequence analysis of these exons revealed that the predicted amino acid sequence of human c-sis differed by 6% from that of the woolly monkey-derived v-sis. These findings imply that the sis proto-oncogene has been well conserved during primate evolution. By comparison of the known amino acid sequences of PDGF peptides with the predicted human c-sis protein, it was possible to demonstrate that this human proto-oncogene is the structural gene encoding one of the two major polypeptides of this potent mitogen for connective tissue cells. |
