| First Author | Malissen M | Year | 1984 |
| Journal | Cell | Volume | 37 |
| Issue | 3 | Pages | 1101-10 |
| PubMed ID | 6611207 | Mgi Jnum | J:7500 |
| Mgi Id | MGI:55970 | Doi | 10.1016/0092-8674(84)90444-6 |
| Citation | Malissen M, et al. (1984) Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell 37(3):1101-10 |
| abstractText | The germ-line joining (J) gene segments and constant (C) genes encoding the beta chain of the mouse T cell antigen receptor have been isolated on a single cosmid clone. There are two constant genes, C beta 1 and C beta 2, each associated with a cluster of J beta gene segments. The nucleotide sequences of the C beta 2 gene and of the J beta 2 cluster gene segments have been determined. The coding sequence of the C beta 2 gene is very similar to the sequence of a cDNA clone encoded by the C beta 1 gene. The C beta 2 gene has four exons; exon-intron structure does not obviously correspond to the functional domains of the protein. The J beta 2 gene segment cluster contains six functional J gene segments. We have isolated specific probes for the C beta 1, C beta 2, J beta 1, and J beta 2 regions to examine DNA rearrangements in T lymphocytes. DNA rearrangements can occur in both J beta gene segment clusters, and both C beta genes appear functional. |
