First Author | Guerrero I | Year | 1984 |
Journal | Science | Volume | 225 |
Issue | 4666 | Pages | 1041-3 |
PubMed ID | 6089339 | Mgi Jnum | J:7575 |
Mgi Id | MGI:56045 | Doi | 10.1126/science.6089339 |
Citation | Guerrero I, et al. (1984) Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma. Science 225(4666):1041-3 |
abstractText | Treatment of mice with the carcinogen N-methylnitrosourea results in the development of thymic lymphomas with frequent involvement of the N-ras oncogene. The activated mouse N-ras gene was isolated from one of these lymphomas and, by transformation in concert with restriction digestion, a map of the gene was prepared and its approximate boundaries were determined. By means of somatic cell hybrids the normal N-ras gene was found to be unlinked to other members of the ras gene family. |