| First Author | von Deimling OH | Year | 1984 |
| Journal | Biochem Genet | Volume | 22 |
| Issue | 9-10 | Pages | 769-82 |
| PubMed ID | 6517849 | Mgi Jnum | J:7704 |
| Mgi Id | MGI:56173 | Doi | 10.1007/BF00499472 |
| Citation | von Deimling OH (1984) Esterase-23 (ES-23): characterization of a new carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, genetically linked to ES-2 on chromosome 8. Biochem Genet 22(9-10):769-82 |
| abstractText | Genetic variation of a carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, designated ES-23, is described. ES-23 was found in kidney, liver, and intestine. The isozyme was resistant to inhibition by 10(-3) mol/liter eserine and was stained using alpha-naphthyl butyrate or 5-bromoindoxyl acetate as substrate. Five different phenotypes, ES-23A to ES-23E, could be distinguished by disc electrophoresis and by isoelectric focusing. ES-23 is controlled by a structural locus situated within the esterase gene cluster 2 on chromosome 8. An analysis of allele distribution among different strains suggested a separate structural locus for the isozyme, Es-23e, which is closely linked to the loci Es-2, Es-5, Es-7, and Es-11. Of the five phenotypes, only ES-23B was expressed in lung. This variation is apparently controlled by a cis-acting regulatory element, presumably a temporal locus, Es-23t, closely linked to the presumed structural locus Es-23e. |
