| First Author | Hoffenbach A | Year | 1985 |
| Journal | Cell Immunol | Volume | 91 |
| Issue | 1 | Pages | 1-11 |
| PubMed ID | 3882240 | Mgi Jnum | J:7730 |
| Mgi Id | MGI:56199 | Doi | 10.1016/0008-8749(85)90026-7 |
| Citation | Hoffenbach A, et al. (1985) Strain variation of lymphokine production and specific antibody secretion in mice infected with Mycobacterium lepraemurium. Cell Immunol 91(1):1-11 |
| abstractText | Mice from strains showing either phenotypical expression of Bcg gene (C57BL/6, BALB/c, DBA/1, and (C57BL/6 X DBA/2)/F1, CBA, A/J, DBA/2) were infected intravenously with 10(7) Mycobacterium lepraemurium (MLM). The number of acid-fast bacilli (AFB) within the spleens, the ability of spleen cells to produce in vitro interleukin 1 and 2, and the serum levels of specific anti-MLM antibodies were assessed 3 months later. The number of AFB recovered from the spleens of various strains followed the strain distribution of genetically controlled innate resistance established for Mycobacterium bovis infection. A decrease of interleukin 2 production by spleen cells could be detected in C57BL/6, DBA/1, DBA/2 and (C57BL/6 X DBA/2)F1 mice only. The level of anti-MLM antibodies was found to be higher in C57BL/6, BALB/c and A/J mice than in the other strains tested. Thus no evidence appeared of a direct influence of the Bcg gene on lymphokine production and antibody secretion. |
