| First Author | Stallings RL | Year | 1985 |
| Journal | Chromosoma | Volume | 92 |
| Issue | 2 | Pages | 156-63 |
| PubMed ID | 4006599 | Mgi Jnum | J:7894 |
| Mgi Id | MGI:56363 | Doi | 10.1007/BF00328468 |
| Citation | Stallings RL, et al. (1985) Oncogenes and linkage groups: conservation during mammalian chromosome evolution. Chromosoma 92(2):156-63 |
| abstractText | Proto-oncogenes, which represent the cellular progenitors of the transforming genes harbored by acute transforming oncogenic retroviruses, have been highly conserved during vertebrate evolution. In this report, we have assigned experimentally a subset of proto-oncogenes (SRC, ABL, FES, and FMS-all related to the SRC family) to Chinese hamster chromosomes by Southern filter hybridization analyses of DNAs isolated from both somatic cell hybrids and flow-sorted hamster chromosomes. These results demonstrate that several autosomal linkage groups containing proto-oncogenes originated prior to the radiation and speciation of mammals and have remained remarkably stable for nearly 80 million years. |
