First Author | Silver J | Year | 1985 |
Journal | J Virol | Volume | 55 |
Issue | 2 | Pages | 494-6 |
PubMed ID | 4020956 | Mgi Jnum | J:7950 |
Mgi Id | MGI:56419 | Doi | 10.1128/jvi.55.2.494-496.1985 |
Citation | Silver J (1985) A defective ecotropic provirus closely linked to the albino locus. J Virol 55(2):494-6 |
abstractText | A congenic mouse strain (NFS.C) carrying the albino region of chromosome 7 from strain C58/Lw on an ecotropic virus-negative NFS background inherited a noninducible but apparently full-size provirus reactive with an ecotropic virus-specific probe. This unexpressed ecotropic provirus maps close to the albino locus but is distinct from the Fgv-1 provirus located in the same region. The presence of this unique provirus in the albino region of chromosome 7 is potentially important, since it may provide a means of obtaining molecular clones of a chromosomal region, deletions of which are involved in profound metabolic, reproductive, and embryological abnormalities. |