| First Author | Landolfi NF | Year | 1985 |
| Journal | Immunogenetics | Volume | 22 |
| Issue | 2 | Pages | 159-67 |
| PubMed ID | 3875551 | Mgi Jnum | J:7976 |
| Mgi Id | MGI:56445 | Doi | 10.1007/BF00563513 |
| Citation | Landolfi NF, et al. (1985) Activation of T lymphocytes results in an increase in H-2-encoded neuraminidase. Immunogenetics 22(2):159-67 |
| abstractText | The endogenous neuraminidase activity of various mouse lymphoid subpopulations and tissue compartments was examined by a sensitive fluorometric assay. These analyses indicated that activated T lymphocytes possessed a significantly higher level of intracellular neuraminidase than activated B or resting T or B lymphocytes. Examination of the level of neuraminidase in bone marrow, thymus, lymph node, and unfractionated spleen indicated that these lymphoid tissues contained significantly less neuraminidase than was detected in stimulated T cells. Kinetic studies revealed that the majority of the increase in neuraminidase activity occurred between 24 and 48 h following stimulation. Analysis of activated T lymphocytes prepared from a panel of inbred mouse strains indicated that cells from mice of the H-2v haplotype, which possess the Neu-1a allele and are deficient in liver neuraminidase, exhibited a level of activity which was significantly lower than that detected in stimulated T cells from other mouse strains. These results indicate that the endogenous neuraminidase activity of T lymphocytes increases upon stimulation, and that the level of this enzyme activity in lymphoid cells is also controlled by the Neu-1 locus, which is located in the H-2 region of the major histocompatibility complex. |
