| First Author | Kurtz ME | Year | 1985 |
| Journal | J Immunol | Volume | 135 |
| Issue | 4 | Pages | 2847-52 |
| PubMed ID | 2411816 | Mgi Jnum | J:7984 |
| Mgi Id | MGI:56453 | Doi | 10.4049/jimmunol.135.4.2847 |
| Citation | Kurtz ME, et al. (1985) CTL and serologically defined antigens of B2m,H-3 region. J Immunol 135(4):2847-52 |
| abstractText | The antigens of the B2m,H-3 region of 13 chromosome 2 congenic strains and seven inbred strains have been studied by using CML and serologic techniques. Nine patterns of cross-reactivity have been defined by CML assays. These results are in agreement with an extend previously described cross-reactivity studies. The reactivities of three monoclonal antibodies previously thought to be reacting with B2M-B are shown to differ: Ly-m11 and J-5 react with cells of strain B10-pa,at and clone 23 does not. Two H-3 region loci are hypothesized on the basis of CML and serologic activity: B2m and H-3. The CTL responses to the B2M antigens are H-2K restricted; the CTL responses to H-3 antigens are H-2D restricted. The restriction of the response to the H-3 antigen requires effector-target identity of the H-2D molecule but not the B2M molecule of the class I antigen. These loci have been separated by recombination from H-42 in the production of the congenic strain B10.FS-a. A gene order of B2m, H-3, H-42 is suggested. |
