| First Author | Winter E | Year | 1985 |
| Journal | EMBO J | Volume | 4 |
| Issue | 11 | Pages | 2861-7 |
| PubMed ID | 2998759 | Mgi Jnum | J:8090 |
| Mgi Id | MGI:56559 | Doi | 10.1002/j.1460-2075.1985.tb04015.x |
| Citation | Winter E, et al. (1985) Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes. EMBO J 4(11):2861-7 |
| abstractText | Four potentially productive and two non-productive VDJ gene segments were isolated from the DNA of mouse B-lymphocytes which had been polyclonally activated by bacterial lipopolysaccharide (LPS). Three VDJ regions exhibit VH genes which stem from two novel VH gene families. The complexity of these families is 5-9 genes. One of the non-productive VDJ regions exhibits a D segment which may have been generated by joining of two DSP2 segments. Both non-productive VDJ regions appear to contain rearranged pseudo VH genes. Three potential somatic mutations distributed over two productive VDJ regions are observed. |
