| First Author | Jolicoeur P | Year | 1985 |
| Journal | J Virol | Volume | 56 |
| Issue | 3 | Pages | 1045-8 |
| PubMed ID | 4068142 | Mgi Jnum | J:8107 |
| Mgi Id | MGI:56576 | Doi | 10.1128/jvi.56.3.1045-1048.1985 |
| Citation | Jolicoeur P, et al. (1985) Mouse chromosomal mapping of a murine leukemia virus integration region (Mis-1) first identified in rat thymic leukemia. J Virol 56(3):1045-8 |
| abstractText | We have previously identified a region of genomic DNA which constitutes the site of frequent provirus integration in rat thymomas induced by Moloney murine leukemia virus (Lemay and Jolicoeur, Proc. Natl. Acad. Sci. USA 81:38-42, 1984). This genetic locus is now designated Mis-1 (Moloney integration site). Cellular sequences homologous to Mis-1 are present in mouse DNA. Using a series of hamster-mouse somatic cell hybrids, we mapped the Mis-1 locus to mouse chromosome 15. Frequent chromosome 15 aberrations have been described in mouse thymomas. Mis-1 represents a putative new oncogene which might be involved in the initiation or maintenance or both of these neoplasms. |
