| First Author | Takeuchi T | Year | 1986 |
| Journal | J Clin Invest | Volume | 77 |
| Issue | 3 | Pages | 1038-41 |
| PubMed ID | 3753985 | Mgi Jnum | J:17768 |
| Mgi Id | MGI:65796 | Doi | 10.1172/JCI112357 |
| Citation | Takeuchi T, et al. (1986) Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7. J Clin Invest 77(3):1038-41 |
| abstractText | Pancreatic polypeptide and neuropeptide Y share 50% amino acid homology (18 out of 36 residues), suggesting that they may have common ancestral origins. cDNA clones complementary to human mRNAs encoding pancreatic polypeptide and neuropeptide Y were used to detect specific human genomic DNA sequences in human-mouse somatic cell hybrid lines. The pancreatic polypeptide gene (PPY) segregated with human chromosome 17, while the neuropeptide Y gene (NPY) segregated with human chromosome 7. Examination of cell hybrids with chromosomal rearrangements assigned PPY to the p11.1-qter region and NPY to the pter-q22 region of their respective chromosomes. |
